BOOKS - Charney and Nestler's Neurobiology of Mental Illness
Charney and Nestler
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Charney and Nestler's Neurobiology of Mental Illness
Author: Dennis S. Charney MD
Year: 2018
Format: PDF
File size: PDF 60 MB
Language: English



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Charney and Nestler's Neurobiology of Mental Illness: A Comprehensive Guide to Understanding the Biological Basis of Mental Disorders Introduction: The field of psychiatry has witnessed intense debates in recent years, particularly after the publication of the DSM-5, regarding the traditional diagnosis-oriented approach and the biological dimension-based RDoC research domain criteria approach. Charney and Nestler's Neurobiology of Mental Illness stands as an authoritative foundation for translating laboratory information into clinical treatment, and its fifth edition delves deeper into these controversies, offering a wider perspective on the future of psychiatric diagnosis. This book provides a comprehensive overview of the basic science and underpinnings of mental disorders, highlighting their practical clinical significance. Section 1: Methods for Examining the Biological Basis of Mental Illness This section has been expanded to reflect critical technical advances, including powerful sequencing technologies, epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. These methodologies offer groundbreaking insights into the brain and translate preclinical and clinical research into much-needed breakthroughs in therapeutic tools.
Charney and Nestler's Neurobiology of Mental Disease: A Comprehensive Guide to Understanding the Biological Basis of Mental Disorders Introduction: The field of psychiatry has been интенсивные дебаты в последние годы, особенно после публикации DSM-5, относительно традиционного подхода, ориентированного на диагностику, и подхода RDoC на основе биологических измерений «Нейробиология психических заболеваний» Чарни и Нестлера выступает в качестве авторитетной основы для перевода лабораторной информации в клиническое лечение, и ее пятое издание углубляется в эти противоречия, предлагая более широкий взгляд на будущее психиатрической диагностики. Эта книга содержит всесторонний обзор фундаментальной науки и основ психических расстройств, подчеркивая их практическое клиническое значение. Раздел 1: Методы изучения биологической основы психических заболеваний Этот раздел был расширен, чтобы отразить критические технические достижения, включая мощные технологии секвенирования, эпигенетику, биологию стволовых клеток, оптогенетику, функционирование нервных цепей, когнитивную нейробиологию и визуализацию мозга. Эти методологии предлагают новаторское понимание мозга и превращают доклинические и клинические исследования в столь необходимые прорывы в терапевтических инструментах.
Charney and Nestler's Neurobiology of Mental Disease: A Comprehensive Guide to Understanding the Biological Basis of Mental Disorders Introduction: champ de psychiatry has been débat intense ces dernières années, surtout après la publication du DSM-5, une approche relativement traditionnelle axée sur le diagnostic, et l'approche RDoC basée sur les mesures biologiques « Neurosciences des maladies mentales » de Charney et Nestler sert de base de référence pour la traduction de l'information de laboratoire en traitement clinique, et sa cinquième édition s'enfonce dans ces contradictions, offrant une vision plus large de l'avenir du diagnostic psychiatrique. Ce livre donne un aperçu complet de la science fondamentale et des fondements des troubles mentaux, soulignant leur importance clinique pratique. Section 1 : Méthodes d'étude du fondement biologique de la maladie mentale Cette section a été élargie pour refléter les progrès techniques critiques, notamment les technologies de séquençage puissantes, l'épigénétique, la biologie des cellules souches, l'optogénétique, le fonctionnement des circuits nerveux, la neuroscience cognitive et l'imagerie cérébrale. Ces méthodologies offrent une compréhension novatrice du cerveau et transforment la recherche préclinique et clinique en des percées très nécessaires dans les outils thérapeutiques.
Charney and Nestler's Neurobiology of Mental Disease: A Comprehensive Guide to Understanding the Biological Basis of Mental Disorders Introduction: campo de psychiatry has been intenso debate en los últimos , especialmente después de la publicación del DSM-5, relativo al enfoque tradicional centrado en el diagnóstico, y el enfoque RDoC basado en mediciones biológicas «Neurociencia de enfermedades mentales» de Charney y Nestler actúa como una base autorizada para traducir la información de laboratorio en tratamiento clínico, y su quinta edición ahonda en estas contradicciones, ofreciendo una visión más amplia del futuro del diagnóstico psiquiátrico. Este libro ofrece una revisión completa de la ciencia básica y los fundamentos de los trastornos mentales, destacando su importancia clínica práctica. Sección 1: Métodos de estudio de la base biológica de las enfermedades mentales Esta sección se ha ampliado para reflejar avances técnicos críticos, incluyendo potentes tecnologías de secuenciación, epigenética, biología de células madre, optogenética, funcionamiento de circuitos nerviosos, neurociencia cognitiva y visualización cerebral. Estas metodologías ofrecen una comprensión innovadora del cerebro y convierten la investigación preclínica y clínica en avances muy necesarios en las herramientas terapéuticas.
Charney and Nestler's Neurobiology of Mental Disease: A Comprehensive Guide to Understanding the Biological Basis of Mental Disorders Introduction: The field of psichiatry ha been intenso dibattito negli ultimi anni, soprattutto dopo la pubblicazione del DSM-5, relativamente all'approccio tradizionale basato sulla diagnostica, e l'approccio del RDoC sulla base delle misurazioni biologiche della Neuroscienze delle Malattie Mentali di Charney e Nestler funge da base autorevole per la traduzione delle informazioni di laboratorio in un trattamento clinico. e la sua quinta edizione approfondisce queste contraddizioni, offrendo una visione più ampia del futuro della diagnosi psichiatrica. Questo libro contiene una panoramica completa della scienza fondamentale e delle basi dei disturbi mentali, sottolineando il loro significato clinico pratico. Sezione 1: Metodi per studiare la base biologica delle malattie mentali Questa sezione è stata ampliata per riflettere i progressi tecnici critici, tra cui potenti tecnologie di sequenziamento, epigenetica, biologia delle cellule staminali, optogenetica, funzionamento delle catene nervose, neuroscienze cognitive e visualizzazione del cervello. Queste metodologie offrono una comprensione innovativa del cervello e trasformano la ricerca preclinica e clinica in una svolta così necessaria negli strumenti terapeutici.
Charney and Nestler's Neurobiology of Mental Disease: A Comprehensive Guide to Understanding the Biological Basis of Mental Disorders Introduction: Das Feld der Psychiatrie hat in den letzten Jahren eine intensive Debatte geführt, insbesondere nach der Veröffentlichung des DSM-5, bezogen auf den traditionellen diagnoseorientierten Ansatz, und dem auf biologischen Messungen basierenden RDoC-Ansatz „Neurobiology of Mental Diseases“ von Charney und Nestler als maßgebliche Grundlage für die Übersetzung von Laborinformationen in die klinische Behandlung, und seine fünfte Ausgabe vertieft sich in diese Widersprüche und bietet einen breiteren Blick auf die Zukunft der psychiatrischen Diagnostik. Dieses Buch bietet einen umfassenden Überblick über die Grundlagenforschung und die Grundlagen psychischer Störungen und unterstreicht deren praktische klinische Bedeutung. Abschnitt 1: Methoden zur Untersuchung der biologischen Grundlagen psychischer Erkrankungen Dieser Abschnitt wurde erweitert, um kritische technische Fortschritte widerzuspiegeln, darunter leistungsstarke Sequenzierungstechnologien, Epigenetik, Stammzellbiologie, Optogenetik, Nervenkreislauffunktion, kognitive Neurobiologie und Bildgebung des Gehirns. Diese Methoden bieten bahnbrechende Einblicke in das Gehirn und verwandeln die präklinische und klinische Forschung in dringend benötigte Durchbrüche in therapeutischen Instrumenten.
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Charney ve Nestler'in Zihinsel Hastalıkların Nörobiyolojisi: Zihinsel Bozuklukların Biyolojik Temelini Anlamak İçin Kapsamlı Bir Rehber Giriş: Psikiyatri alanı son yıllarda, özellikle DSM-5'in yayınlanmasından sonra, geleneksel tanı odaklı yaklaşım ve RDoC biyolojik ölçüm temelli yaklaşım ile ilgili yoğun bir tartışma olmuştur. Charney ve Nestler'in "Akıl Hastalığının Nörobiyolojisi", laboratuvar bilgilerini klinik tedaviye çevirmek için yetkili bir temel olarak hareket eder ve beşinci baskısı, psikiyatrik tanının geleceği hakkında daha geniş bir bakış açısı sunarak bu çelişkileri inceler. Bu kitap, zihinsel bozuklukların temel bilimi ve temelleri hakkında kapsamlı bir genel bakış sunmakta ve pratik klinik önemini vurgulamaktadır. Bölüm 1: Zihinsel Hastalıkların Biyolojik Temellerini İnceleme Yöntemleri Bu bölüm, güçlü dizileme teknolojileri, epigenetik, kök hücre biyolojisi, optogenetik, nöral devre işleyişi, bilişsel sinirbilim ve beyin görüntüleme gibi kritik teknik gelişmeleri yansıtacak şekilde genişletilmiştir. Bu metodolojiler beyinde çığır açan bilgiler sunar ve klinik öncesi ve klinik araştırmaları terapötik araçlarda çok ihtiyaç duyulan atılımlara dönüştürür.
علم الأعصاب للأمراض العقلية لدى تشارني ونيستلر: دليل شامل لفهم الأساس البيولوجي للاضطرابات العقلية مقدمة: كان مجال الطب النفسي نقاشًا حادًا في السنوات الأخيرة، خاصة بعد نشر DSM-5، فيما يتعلق بالنهج التقليدي الموجه نحو التشخيص، ونهج RDoC القائم على القياس البيولوجي يعمل «علم الأحياء العصبي للأمراض العقلية» لتشارني ونستلر كأساس موثوق لترجمة المعلومات المختبرية إلى علاج سريري، وتتعمق نسختها الخامسة في هذه التناقضات، مما يوفر نظرة أوسع لمستقبل التشخيص النفسي. يقدم هذا الكتاب نظرة عامة شاملة على العلوم الأساسية وأسس الاضطرابات العقلية، مما يسلط الضوء على أهميتها السريرية العملية. القسم 1: طرق دراسة الأساس البيولوجي للأمراض العقلية تم توسيع هذا القسم ليعكس التطورات التقنية الحاسمة، بما في ذلك تقنيات التسلسل القوية، وعلم التخلق، وعلم بيولوجيا الخلايا الجذعية، وعلم البصريات الوراثي، وعمل الدائرة العصبية، وعلم الأعصاب المعرفي، وتصوير الدماغ. تقدم هذه المنهجيات رؤى رائدة في الدماغ وتحول الأبحاث قبل السريرية والسريرية إلى اختراقات تشتد الحاجة إليها في الأدوات العلاجية.

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